Effects of the N-Ras Oncogene on the Expression of Other Cellular Genes in CO25 Myoblast Cells
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چکیده
Transformation of fibroblast cells by v-abl oncogene involved overexpression of the c-myc (5) or of the cellular protein p53 (6). Two proto-oncogenes, cmyc and c-K-ras, have been shown to cooperate in the transformation of secondary rat embryo fibroblasts (7). Oncogenic activation of c-myc occurs mainly through constituve and elevated expression of its gene product and generally requires cooperation with at least one additional oncogene, such as ras or bcl-2 (8,9).
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تاریخ انتشار 2000